AckachukwuIbezimVisiting Scientist

University of Nigeria, Nsukka

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I hold BS degree in Pure and Industrial Chemistry and MS in Pharmaceutical and Medicinal Chemistry from the University of Nigeria, Nsukka.

My project in CDIPD includes biological testing of hits obtained from the in silico studies with the emphases on antiparasitic and anticancer activities. Promissing in silico hits will be validated in variery of models, starting from the enzymatic assays to whole organism screening and, finally, to in vivo proof-of-concept.

PUBLICATIONS

Experimental and In-Silico Investigation of Anti-Microbial Activity of 1-Chloro-2-Isocyanatoethane Derivatives of Thiomorpholine, Piperazine and Morpholine. PLoS One. 2017 Jan 20;12(1):e0170150. doi: 10.1371/journal.pone.0170150. eCollection 2017. Nwuche CO, Ujam OT, Ibezim A, Ujam IB.

Oxazin-5-Ones as a Novel Class of Penicillin Binding Protein Inhibitors: Design, Synthesis and Structure Activity Relationship. PLoS One. 2016 Oct 17;11(10):e0163467. doi: 10.1371/journal.pone.0163467. eCollection 2016. Onoabedje EA, Ibezim A, Okafor SN, Onoabedje US, Okoro UC.

Exploring Cancer Therapeutics with Natural Products from African Medicinal Plants, Part II: Alkaloids, Terpenoids and Flavonoids. Anticancer Agents Med Chem. 2016;16(1):108-27. Review. Nwodo JN, Ibezim A, Simoben CV, Ntie-Kang F.

Anti-trypanosomal activity of nigerian plants and their constituents. Molecules. 2015 Apr 28;20(5):7750-71. doi: 10.3390/molecules20057750. Review. Nwodo NJ, Ibezim A, Ntie-Kang F, Adikwu MU, Mbah CJ.

Exploring Cancer Therapeutics with Natural Products from African Medicinal Plants, Part I: Xanthones, Quinones, Steroids, Coumarins, Phenolics and other Classes of Compounds. Anticancer Agents Med Chem. 2015;15(9):1092-111. Review. Simoben CV, Ibezim A, Ntie-Kang F, Nwodo JN, Lifongo LL.

Molecular modeling of potential anticancer agents from African medicinal plants. J Chem Inf Model. 2014 Sep 22;54(9):2433-50. doi: 10.1021/ci5003697. Epub 2014 Aug 25. Ntie-Kang F, Nwodo JN, Ibezim A, Simoben CV, Karaman B, Ngwa VF, Sippl W, Adikwu MU, Mbaze LM.

Autotaxin inhibition: development and application of computational tools to identify site-selective lead compounds. Bioorg Med Chem. 2013 Sep 1;21(17):5548-60. doi: 10.1016/j.bmc.2013.05.061. Epub 2013 Jun 11. Norman DD, Ibezim A, Scott WE, White S, Parrill AL, Baker DL.