RogerLiningtonAssociate Professor, University of California Santa Cruz

Chemistry & Biochemistry

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At the University of California, Santa Cruz, I lead a multi-disciplinary group focused on the discovery, isolation and synthetic modification of natural products, with a particular focus on marine-derived bacterial sources.



Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei. ACS Chem Biol. 2015 Oct 16;10(10):2373-81. doi: 10.1021/acschembio.5b00308. Epub 2015 Aug 13. Schulze CJ, Donia MS, Siqueira-Neto JL, Ray D, Raskatov JA, Green RE, McKerrow JH, Fischbach MA, Linington RG.

Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei. J Nat Prod. 2013 Apr 26;76(4):630-41. doi: 10.1021/np300834q. Epub 2013 Feb 27. Sanchez LM, Knudsen GM, Helbig C, De Muylder G, Mascuch SM, Mackey ZB, Gerwick L, Clayton C, McKerrow JH, Linington RG.

Hit-to-lead development of the chamigrane endoperoxide merulin A for the treatment of African sleeping sickness. PLoS One. 2012;7(9):e46172. doi: 10.1371/journal.pone.0046172. Epub 2012 Sep 27. Navarro G, Chokpaiboon S, De Muylder G, Bray WM, Nisam SC, McKerrow JH, Pudhom K, Linington RG.